TL;DR: This article is an authors’ reply to a comment about an original article concerning the 2014 and 2015 chikungunya epidemics in Managua, Nicaragua. In 2010, Manimunda et al. first suggested that an inverse association existed between the level of chikungunya virus (CHIKV) seroprevalence and the proportion of inapparent CHIKV infection. This authors’ reply was the first time a systematic search of the literature (details provided here) was used to assess the hypothesis. In short, an inverse association was evident from 0% to 40% CHIKV seroprevalence when examining populations that were newly exposed to CHIKV. At >40% CHIKV seroprevalence, the trend was positive but the uncertainty was much higher.
Erratum: The data we presented in the original article had minor errors. The corrected data is presented in Table 4 of this paper. Both the original figure and the corrected figure (shown above) result in the same conclusion. Please contact me if you would like a high resolution version of the corrected figure.
Article availability: The freely available version of the published article can be found here. The paywalled version of the published article can be found here. If you have trouble accessing the article or wish to ask a question about it, please contact me.